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KMID : 0043320030260020147
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Archives of Pharmacal Research
2003 Volume.26 No. 2 p.147 ~ p.150
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A DNA Strand-Nicking Principle of a Higher Plant, Caesalpinia sappan
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Mar WC
Lee HT/Je KH/Choi HY/Seo EK
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Abstract
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To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosee) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation , which led to the isolation of a known compound, brazilin (7) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.
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